Search results for " Transport"

Influence of negative allosteric cooperativity in cation transport.

1992

Abstract The bis-macrocyclic ether5 seems to have a negative allosteric cooperativity and is able to transport double the amount of Na+ and K+ cations as monocyclic systems. This compound could be used as a simple model of the plasma membrane Na+−K+ ATPase which actively pumps Na+ out and K+ into the cell, respectively.

Tellurite-dependent blackening of bacteria emerges from the dark ages

2019

Environmental contextAlthough tellurium is a relatively rare element in the earth’s crust, its concentration in some niches can be naturally high owing to unique geology. Tellurium, as the oxyanion, is toxic to prokaryotes, and although prokaryotes have evolved resistance to tellurium, no universal mechanism exists. We review the interaction of tellurite with prokaryotes with a focus on those unique strains that thrive in environments naturally rich in tellurium. AbstractThe timeline of tellurite prokaryotic biology and biochemistry is now over 50 years long. Its start was in the clinical microbiology arena up to the 1970s. The 1980s saw the cloning of tellurite resistance determinants whil…

The effects of nitric oxide on striatal serotoninergic transmission involve multiple targets: an in vivo microdialysis study in the awake rat

2004

Abstract The role of endogenous nitric oxide (NO) in N -methyl- d -aspartate (NMDA)-induced modulation of serotonin (5-HT) release in the striatum of freely moving rats has been studied using microdialysis technique. NMDA-induced increase in 5-HT release was significantly inhibited by selective nitric oxide synthase (nNOS) inhibitor S -methylthiocitrulline (S-Me-TC), ONOO − scavenger l -cysteine ( l -cys), and guanylate cyclase (GC) inhibitor 1 H [1,2,4]oxadiazolo[4,3- a ]quinoxalin-1-one (ODQ). These data suggest that modulation of 5-HT levels is linked to the formation of NO produced by NMDA receptor activation and that endogenously produced NO increases 5-HT concentrations both by stimul…

Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms

2014

The succinct metaphor, ‘the immune system's loaded gun', has been used to describe the role of mast cells (MCs) due to their storage of a wide range of potent pro-inflammatory and antimicrobial mediators in secretory granules that can be released almost instantly on demand to fight invaders. Located at host–environment boundaries and equipped with an arsenal of pattern recognition receptors, MCs are destined to be rapid innate sensors of pathogens penetrating endothelial and epithelial surfaces. Although the importance of MCs in antimicrobial and antiparasitic defense has long been appreciated, their role in raising the alarm against viral infections has been noted only recently. Work on cy…

A Fuzzy Chance-constraint Programming Model for a Home Health Care Routing Problem with Fuzzy Demand

2017

Can sucrose content in the phloem sap reaching field pea seeds (Pisum sativum L.) be an accurate indicator of seed growth potential ?

2003

The composition of the translocates reaching the seeds of pea plants having various nitrogen (N) nutrition regimes was investigated under field situations. Sucrose flow in the phloem sap increased with the node number, but was not significantly different between N nutrition levels. Because N deficiency reduced the number of flowering nodes and the number of seeds per pod, the sucrose flow bleeding from cut peduncles was divided by the number of seeds to give the amount of assimilates available per seed. The sucrose concentration in phloem sap supplied to seeds at the upper nodes was higher than that at the lower nodes. The flow of sucrose delivered to the seeds during the cell division peri…

Centrifuge tests on strip footings on sand with a weak layer

2017

Tests on small-scale physical models of a strip footing resting on a dense sand bed containing a thin horizontal weak soil layer were carried out at normal gravity (1 g ). The results, reported in a companion paper, point out that the weak layer plays an important role in the failure mechanism and the ultimate bearing capacity of the footing if it falls within the ground volume relevant to the behaviour of the sand–footing system. The same problem was also investigated by means of centrifuge tests on reduced-scale models at 25 g and 40 g . The results of these tests, reported and discussed in this paper, confirm that failure mechanisms are governed substantially by the presence of the weak…

Transport policy and climate change: How to decide when experts disagree

2008

Abstract Transport is the sector with the fastest growth of greenhouse gases emissions in many countries. Accumulation of these emissions may cause uncertain and irreversible adverse climate change impacts. In this context, we use the analytic hierarchy process (AHP) to face the question on how to select the best transport policy if the experts have different opinions and beliefs on the occurrence of these impacts. Thus, both the treatment of uncertainty and dissent are examined for the ranking of transport policies. The opinions of experts have been investigated by a means of a survey questionnaire. A sensitivity analysis of the experts’ weights and the criteria’ weights confirms the robus…

Subcellular targeting of multiligand-binding protein gC1qR.

1999

Abstract gC1q receptor, a protein originally described as the cell surface receptor for the globular heads of complement factor C1q, has been found to bind human H-kininogen with high affinity and specificity. Therefore, gC1qR has been considered candidate kininogen docking site on the surfaces of platelets, neutrophils and endothelial cells. Recent work demonstrating that gC1qR is an intracellular protein that is tightly associated with mitochondria rather than targeted to the cell surface has challenged this view. To further probe cellular trafficking routes of gC1qR, we overexpressed human gC1qR in a mammalian cell and monitored cell surface exposure of recombinant gC1qR by virtue of its…

Sabiedriskā transporta sasniedzamības novērtēšana Aizputes, Kuldīgas un Skrundas novados

2020

Iedzīvotāju mobilitātes iespējas lielā mērā ietekmē vietu attīstību. Sabiedriskā transporta sasniedzamība tam ir nozīmīgs priekšnosacījums. Arvien aktuāli ir jautājumi par sabiedriskā transporta pakalpojumu efektivitāti, kas lielā mērā ir atkarīga no iedzīvotāju skaita un izvietojuma teritorijā. Maģistra darbā “Sabiedriskā transporta sasniedzamības novērtēšana Aizputes, Kuldīgas un Skrundas novados” raksturota metode, kas balstīta uz kvantitatīviem datiem un to telpisko analīzi, lai novērtētu sabiedriskā transporta sasniedzamību. Mērķis - identificēt teritorijas, kur nepieciešami sasniedzamības uzlabojumi. Izvēlētā metode vērtējama kā salīdzinoši detalizēta. Rezultāti attiecībā uz Aizputes,…